Novel bacterial ADP-ribosylating toxins: structure and function
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چکیده
منابع مشابه
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ADP-ribosyltransferases (ADP-RTs) are a family of enzymes secreted by pathogenic bacteria. They catalyse the hydrolysis of NAD+ and the transfer of the ADPribosyl group onto specific target proteins [1,2]. Figure 1 Although ADP-RTs are important drug targets, only few inhibitors are known so far. The high selectivity of these inhibitors suggest different mechanism of binding to the ADP-RTs acti...
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ژورنال
عنوان ژورنال: Nature Reviews Microbiology
سال: 2014
ISSN: 1740-1526,1740-1534
DOI: 10.1038/nrmicro3310